Macrophages contain a neutral cholesteryl ester hydrolase that can be activated by cAMP-
dependent protein kinase. Immunological studies strongly suggest that hormone-sensitive
lipase (HSL) is probably responsible for the cholesteryl ester hydrolase activity in
macrophages; however, due to the very low level of expression in macrophages, it has been
difficult to determine whether the macrophage cholesteryl ester hydrolase and adipose HSL
are, in fact, products of the same gene. We have used the sensitive polymerase chain …