The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a complex disease trait
where genetic variations and environment interact to determine disease progression. The
association of PNPLA3 with advanced disease has been consistently demonstrated but
many other modifier genes remain unidentified. In NAFLD, increased fatty acid oxidation
produces high levels of reactive oxygen species. Manganese-dependent superoxide
dismutase (MnSOD), encoded by the SOD2 gene, plays an important role in protecting cells …
where genetic variations and environment interact to determine disease progression. The
association of PNPLA3 with advanced disease has been consistently demonstrated but
many other modifier genes remain unidentified. In NAFLD, increased fatty acid oxidation
produces high levels of reactive oxygen species. Manganese-dependent superoxide
dismutase (MnSOD), encoded by the SOD2 gene, plays an important role in protecting cells …