The proline-rich domain and the microtubule binding domain of protein tau acting as RNA binding domains
XS Wang, DL Wang, J Zhao, MH Qu… - Protein and peptide …, 2006 - ingentaconnect.com
Protein and peptide letters, 2006•ingentaconnect.com
Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to
RNA nonsequence-specifically via electrostatic interaction. This binding inhibits the activity
of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA
has opportunities to interact with tau in cells.
RNA nonsequence-specifically via electrostatic interaction. This binding inhibits the activity
of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA
has opportunities to interact with tau in cells.
Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA nonsequence- specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.
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