[HTML][HTML] The role of post-translational modifications in the phase transitions of intrinsically disordered proteins
I Owen, F Shewmaker - International journal of molecular sciences, 2019 - mdpi.com
I Owen, F Shewmaker
International journal of molecular sciences, 2019•mdpi.comAdvances in genomics and proteomics have revealed eukaryotic proteomes to be highly
abundant in intrinsically disordered proteins that are susceptible to diverse post-translational
modifications. Intrinsically disordered regions are critical to the liquid–liquid phase
separation that facilitates specialized cellular functions. Here, we discuss how post-
translational modifications of intrinsically disordered protein segments can regulate the
molecular condensation of macromolecules into functional phase-separated complexes.
abundant in intrinsically disordered proteins that are susceptible to diverse post-translational
modifications. Intrinsically disordered regions are critical to the liquid–liquid phase
separation that facilitates specialized cellular functions. Here, we discuss how post-
translational modifications of intrinsically disordered protein segments can regulate the
molecular condensation of macromolecules into functional phase-separated complexes.
Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly abundant in intrinsically disordered proteins that are susceptible to diverse post-translational modifications. Intrinsically disordered regions are critical to the liquid–liquid phase separation that facilitates specialized cellular functions. Here, we discuss how post-translational modifications of intrinsically disordered protein segments can regulate the molecular condensation of macromolecules into functional phase-separated complexes.
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