Potential of the antibody against cis–phosphorylated tau in the early diagnosis, treatment, and prevention of Alzheimer disease and brain injury
Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) share a common
neuropathologic signature—neurofibrillary tangles made of phosphorylated tau—but do not
have the same pathogenesis or symptoms. Although whether traumatic brain injury (TBI)
could cause AD has not been established, CTE is shown to be associated with TBI. Until
recently, whether and how TBI leads to tau-mediated neurodegeneration was unknown. The
unique prolyl isomerase Pin1 protects against the development of tau-mediated …
neuropathologic signature—neurofibrillary tangles made of phosphorylated tau—but do not
have the same pathogenesis or symptoms. Although whether traumatic brain injury (TBI)
could cause AD has not been established, CTE is shown to be associated with TBI. Until
recently, whether and how TBI leads to tau-mediated neurodegeneration was unknown. The
unique prolyl isomerase Pin1 protects against the development of tau-mediated …
