Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
S Taniguchi, N Suzuki, M Masuda, S Hisanaga… - Journal of Biological …, 2005 - ASBMB
Tau protein is the major component of the intraneuronal filamentous inclusions that
constitute defining neuropathological characteristics of Alzheimer's disease and other
tauopathies. The discovery of tau gene mutations in familial forms of frontotemporal
dementia has established that dysfunction of the tau protein is sufficient to cause
neurodegeneration and dementia. Here we have tested 42 compounds belonging to nine
different chemical classes for their ability to inhibit heparin-induced assembly of tau into …
constitute defining neuropathological characteristics of Alzheimer's disease and other
tauopathies. The discovery of tau gene mutations in familial forms of frontotemporal
dementia has established that dysfunction of the tau protein is sufficient to cause
neurodegeneration and dementia. Here we have tested 42 compounds belonging to nine
different chemical classes for their ability to inhibit heparin-induced assembly of tau into …
