The nuclear pore complex (NPC) is a large multimeric structure that is interspersed
throughout the membrane of the nucleus and consists of at least 33 protein components.
Individual components cooperate within the nuclear pore to facilitate selective passage of
materials between the nucleus and cytoplasm while simultaneously performing pore-
independent roles throughout the cell. NPC dysfunction is a hallmark of neurodegenerative
disorders including Alzheimer's disease, Huntington's disease, and amyotrophic lateral …