Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions

X Dong, S Sun, L Zhang, S Kim, Z Tu, C Montagna… - Aging cell, 2021 - Wiley Online Library
X Dong, S Sun, L Zhang, S Kim, Z Tu, C Montagna, AY Maslov, Y Suh, T Wang, J Campisi…
Aging cell, 2021Wiley Online Library
Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition
to causing cellular senescence and apoptosis, telomere shortening has been found to affect
gene expression in subtelomeric regions. Here, we analyzed the distribution of age‐related
differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types
from 979 human subjects and found significantly more upregulated than downregulated
genes in subtelomeric regions as compared to the genome‐wide average. Our data …
Abstract
Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age‐related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome‐wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.
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