Anti-hepatitis C virus activity of tamoxifen reveals the functional association of estrogen receptor with viral RNA polymerase NS5B
K Watashi, D Inoue, M Hijikata, K Goto, HH Aly… - Journal of biological …, 2007 - ASBMB
Hepatitis C virus (HCV) is a major causative agent of hepatocellular carcinoma. HCV
genome replication occurs in the replication complex (RC) around the endoplasmic
reticulum membrane. However, the mechanisms regulating the HCV RC remain widely
unknown. Here, we used a chemical biology approach to show that estrogen receptor (ESR)
is functionally associated with HCV replication. We found that tamoxifen suppressed HCV
genome replication. Part of ESRα resided on the endoplasmic reticulum membranes and …
genome replication occurs in the replication complex (RC) around the endoplasmic
reticulum membrane. However, the mechanisms regulating the HCV RC remain widely
unknown. Here, we used a chemical biology approach to show that estrogen receptor (ESR)
is functionally associated with HCV replication. We found that tamoxifen suppressed HCV
genome replication. Part of ESRα resided on the endoplasmic reticulum membranes and …
