RyR2 calcium channels in the spotlight—I'm ready for my close up, Dr. Alzheimer!
GE Stutzmann - Cell Calcium, 2021 - Elsevier
While various hypotheses surrounding the etiology of Alzheimer's disease (AD) have waxed
and waned over the years, the calcium hypothesis of aging [1] has maintained its steady
trajectory since the early 1990′ s, albeit often as the understudy. Here, Yao et al.,[2] further
implicate intracellular calcium dysregulation in AD pathogenesis, and focus the spotlight on
the elusive ryanodine receptor-2 isoform.
and waned over the years, the calcium hypothesis of aging [1] has maintained its steady
trajectory since the early 1990′ s, albeit often as the understudy. Here, Yao et al.,[2] further
implicate intracellular calcium dysregulation in AD pathogenesis, and focus the spotlight on
the elusive ryanodine receptor-2 isoform.
