Background Ischemia during kidney transplant causes chronic allograft injury and adversely
affects outcome, but the underlying mechanisms are incompletely understood. In tumors,
oxygen shortage reduces the DNA demethylating activity of the ten-11 translocation (TET)
enzymes, yielding hypermethylated genomes that promote tumor progression. We
investigated whether ischemia similarly induces DNA hypermethylation in kidney transplants
and contributes to chronic injury. Methods We profiled genome-wide DNA methylation in …