Genetic information is recorded in specific DNA sequences that must be protected to
preserve normal cellular function. Genome maintenance pathways have evolved to sense
and repair DNA damage. Importantly, deleterious mutations that occur from mis-repaired
lesions can lead to diseases such as cancer. As eukaryotic DNA is bound by histone
proteins and organized into chromatin, the true in vivo substrate of transcription, replication
and DNA repair is chromatin. Almost 50 years ago, it was found that histones contained the …