Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin)
S Farber, LK Diamond, RD Mercer… - … England Journal of …, 1948 - Mass Medical Soc
S Farber, LK Diamond, RD Mercer, RF Sylvester Jr, JA Wolff
New England Journal of Medicine, 1948•Mass Medical SocIT IS the purpose of this paper to record the results of clinical and hematologic studies on 5
children with acute leukemia treated by the intramuscular injection of a synthetic compound,
4-aminopteroylglutamic acid (aminopterin). This substance is an antagonist to folic acid
regarding the growth of Streptococcus faecalis R. The occurrence of what he interpreted as
an" acceleration phenomenon" in the leukemic process as seen in the marrow and viscera
of children with acute leukemia treated by the injection of folic acid conjugates1 …
children with acute leukemia treated by the intramuscular injection of a synthetic compound,
4-aminopteroylglutamic acid (aminopterin). This substance is an antagonist to folic acid
regarding the growth of Streptococcus faecalis R. The occurrence of what he interpreted as
an" acceleration phenomenon" in the leukemic process as seen in the marrow and viscera
of children with acute leukemia treated by the injection of folic acid conjugates1 …
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia treated by the intramuscular injection of a synthetic compound, 4-aminopteroylglutamic acid (aminopterin). This substance is an antagonist to folic acid regarding the growth of Streptococcus faecalis R.
The occurrence of what he interpreted as an "acceleration phenomenon" in the leukemic process as seen in the marrow and viscera of children with acute leukemia treated by the injection of folic acid conjugates1 — pteroyltriglutamic acid (teropterin) and pteroyldiglutamic acid (diopterin) — and an experience gained from studies on folic . . .
The New England Journal Of Medicine