Directed differentiation of human embryonic stem cells to corneal endothelial cell-like cells: a transcriptomic analysis
Q Song, S Yuan, Q An, Y Chen, FF Mao, Y Liu… - Experimental eye …, 2016 - Elsevier
Corneal endothelial cells (CECs) are a monolayer of cells covering the inner-side of cornea,
playing a pivotal role in keeping the cornea transparent. Because adult CECs have no
proliferative capacity, the loss of CECs during aging or under pathological conditions would
lead to corneal edema, eventually leading to the blindness. Clinically, donated CECs have
been successfully transplanted to treat the diseases of CEC deficiency; however, the source
of CEC donation is very limited. As an alternative cell source for CEC transplantation, CEC …
playing a pivotal role in keeping the cornea transparent. Because adult CECs have no
proliferative capacity, the loss of CECs during aging or under pathological conditions would
lead to corneal edema, eventually leading to the blindness. Clinically, donated CECs have
been successfully transplanted to treat the diseases of CEC deficiency; however, the source
of CEC donation is very limited. As an alternative cell source for CEC transplantation, CEC …