[PDF][PDF] Pluripotent stem cell-based cell therapy—promise and challenges
S Yamanaka - Cell stem cell, 2020 - cell.com
Cell stem cell, 2020•cell.com
Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent
stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable
diseases and injuries. Both ESCs and iPSCs are already being used in clinical trials.
However, we continue to encounter practical issues that limit their use, including their
inherent properties of tumorigenicity, immunogenicity, and heterogeneity. Here, I review two
decades of research aimed at overcoming these three difficulties.
stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable
diseases and injuries. Both ESCs and iPSCs are already being used in clinical trials.
However, we continue to encounter practical issues that limit their use, including their
inherent properties of tumorigenicity, immunogenicity, and heterogeneity. Here, I review two
decades of research aimed at overcoming these three difficulties.
Summary
Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable diseases and injuries. Both ESCs and iPSCs are already being used in clinical trials. However, we continue to encounter practical issues that limit their use, including their inherent properties of tumorigenicity, immunogenicity, and heterogeneity. Here, I review two decades of research aimed at overcoming these three difficulties.
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