Evidence for DNA damage as a biological link between diabetes and cancer
SC Lee, JCN Chan - Chinese medical journal, 2015 - journals.lww.com
Objective: This review examines the evidence that: Diabetes is a state of DNA damage;
pathophysiological factors in diabetes can cause DNA damage; DNA damage can cause
mutations; and DNA mutation is linked to carcinogenesis. Data Sources: We retrieved
information from the PubMed database up to January, 2014, using various search terms and
their combinations including DNA damage, diabetes, cancer, high glucose, hyperglycemia,
free fatty acids, palmitic acid, advanced glycation end products, mutation and …
pathophysiological factors in diabetes can cause DNA damage; DNA damage can cause
mutations; and DNA mutation is linked to carcinogenesis. Data Sources: We retrieved
information from the PubMed database up to January, 2014, using various search terms and
their combinations including DNA damage, diabetes, cancer, high glucose, hyperglycemia,
free fatty acids, palmitic acid, advanced glycation end products, mutation and …