Cancers of the skin are the most common cancers to afflict Americans in the United States with over 1,000,000 new cases estimated to occur in 2008 (ACS, 2008). The primary environmental factor that influences the development of skin cancer is exposure to sunlight, in the ultraviolet B (UVB) wavelengths. Notably, a dramatic increase in the incidence of skin cancers is seen with increasing age (ACS, 2008), as evidenced by the fact that a majority of skin malignancies are found in people over the age of 60 years (Kraemer, 1997; ACS, 2008). However, the mechanisms underpinning the correlation between age and skin cancer are not well understood. New ideas on the link between age and skin cancer have arisen based on age-related accumulation of stromal senescent cells that can lead to a tumorpromoting environment (Krtolica et al., 2001; Krtolica and Campisi, 2002; Dilley et al., 2003; Parrinello et al., 2005; Collado et al., 2007). Combining these recent data from others with data from our laboratory leads us to propose a new paradigm for the role of aging in the development of skin cancer involving the insulin-like growth factor-1 receptor (IGF-1R) pathway (Kuhn et al., 1999; Chuang et al., 2005; Heemst et al., 2005; Kurosu et al., 2005; Samani et al., 2005; Lewis and Spandau, 2008; Lewis et al., 2008).