Effect of feeding a high fat diet on hydrogen sulfide (H2S) metabolism in the mouse
MT Peh, AB Anwar, DSW Ng, MSBM Atan, SD Kumar… - Nitric Oxide, 2014 - Elsevier
Hydrogen sulfide (H 2 S) has complex effects in inflammation with both pro-and anti-
inflammatory actions of this gas reported. Recent work suggests that a deficiency of H 2 S
occurs in, and may contribute to, the chronic inflammation which underpins ongoing
atherosclerotic disease. However, whether a high fat diet, predisposing to atherosclerosis,
affects H 2 S metabolism is not known. In this study we assessed H 2 S metabolism in
different tissues of mice fed a high fat diet for up to 16 weeks. Ex vivo biosynthesis of H 2 S …
inflammatory actions of this gas reported. Recent work suggests that a deficiency of H 2 S
occurs in, and may contribute to, the chronic inflammation which underpins ongoing
atherosclerotic disease. However, whether a high fat diet, predisposing to atherosclerosis,
affects H 2 S metabolism is not known. In this study we assessed H 2 S metabolism in
different tissues of mice fed a high fat diet for up to 16 weeks. Ex vivo biosynthesis of H 2 S …