[HTML][HTML] Apolipoprotein AI stimulates secretion of apolipoprotein E by foam cell macrophages
Apolipoprotein AI (apoA-I) overexpression inhibits atherogenesis in mice, and
apolipoprotein E (apoE) secreted by foam cell macrophages may exert antiatherogenic
effects within the arterial wall. We hypothesized that interaction between apoA-I and apoE
contributed to the antiatherogenic properties of apoA-I, and therefore investigated whether
apoA-I stimulated secretion of apoE by foam cell macrophages. Cholesterol enrichment of
primary murine and human macrophages increased spontaneous apoE secretion 2-fold, as …
apolipoprotein E (apoE) secreted by foam cell macrophages may exert antiatherogenic
effects within the arterial wall. We hypothesized that interaction between apoA-I and apoE
contributed to the antiatherogenic properties of apoA-I, and therefore investigated whether
apoA-I stimulated secretion of apoE by foam cell macrophages. Cholesterol enrichment of
primary murine and human macrophages increased spontaneous apoE secretion 2-fold, as …