[HTML][HTML] miRNA profiling of B-cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes
MicroRNAs (miRNAs) are an important class of small RNAs that regulate gene expression at
the post-transcriptional level. It has become evident that miRNAs are involved in
hematopoiesis, and that deregulation of miRNAs may give rise to hematopoietic
malignancies. The aim of our study was to establish miRNA profiles of naïve, germinal
center (GC) and memory B cells, and validate their expression patterns in normal lymphoid
tissues. Quantitative (q) RT-PCR profiling revealed that several miRNAs were elevated in …
the post-transcriptional level. It has become evident that miRNAs are involved in
hematopoiesis, and that deregulation of miRNAs may give rise to hematopoietic
malignancies. The aim of our study was to establish miRNA profiles of naïve, germinal
center (GC) and memory B cells, and validate their expression patterns in normal lymphoid
tissues. Quantitative (q) RT-PCR profiling revealed that several miRNAs were elevated in …