Polymyositis and Dermatomyositis: (Second of Two Parts)
A Bohan, JB Peter - New England Journal of Medicine, 1975 - Mass Medical Soc
A Bohan, JB Peter
New England Journal of Medicine, 1975•Mass Medical SocLaboratory Features Elevation of sarcoplasmic enzymes in serum (creatine phosphokinase,
aldolase, transaminases and lactic dehydrogenase) is valuable both for diagnosis and for
following the clinical activity and response to treatment. Although some state that the
transaminases are the most reliable, 31, 33, 35 most authorities favor the creatine
phosphokinase. 2 These serum enzymes are not infallible guidelines, for occasionally they
remain entirely within the normal range despite active myositis1, 51; likewise, when muscle …
aldolase, transaminases and lactic dehydrogenase) is valuable both for diagnosis and for
following the clinical activity and response to treatment. Although some state that the
transaminases are the most reliable, 31, 33, 35 most authorities favor the creatine
phosphokinase. 2 These serum enzymes are not infallible guidelines, for occasionally they
remain entirely within the normal range despite active myositis1, 51; likewise, when muscle …
Laboratory Features
Elevation of sarcoplasmic enzymes in serum (creatine phosphokinase, aldolase, transaminases and lactic dehydrogenase) is valuable both for diagnosis and for following the clinical activity and response to treatment. Although some state that the transaminases are the most reliable,31,33,35 most authorities favor the creatine phosphokinase.2
These serum enzymes are not infallible guidelines, for occasionally they remain entirely within the normal range despite active myositis1,51; likewise, when muscle atrophy is extensive in long standing disease, the enzymes may be normal despite active myositis. Motor-neuron diseases, Duchenne muscular dystrophy and other dystrophies, metabolic disorders, endocrinopathies, toxins . . .
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