C-type natriuretic peptide is a growth inhibitor of rat vascular smooth muscle cells
M Furuya, M Yoshida, Y Hayashi, N Ohnuma… - Biochemical and …, 1991 - Elsevier
M Furuya, M Yoshida, Y Hayashi, N Ohnuma, N Minamino, K Kangawa, H Matsuo
Biochemical and biophysical research communications, 1991•ElsevierC-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase
activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA
synthesis of the cells 10-fold more effectively than α-human atrial natriuretic peptide (α-
hANP). The inhibitory effect of CNP was mimicked by 8-bromo-cGMP. The proliferation of
VSMC was also suppressed by CNP more potently than α-hANP, while the peptide was less
active for cGMP augmentation and for vasorelaxation than α-hANP in isolated rat aorta …
activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA
synthesis of the cells 10-fold more effectively than α-human atrial natriuretic peptide (α-
hANP). The inhibitory effect of CNP was mimicked by 8-bromo-cGMP. The proliferation of
VSMC was also suppressed by CNP more potently than α-hANP, while the peptide was less
active for cGMP augmentation and for vasorelaxation than α-hANP in isolated rat aorta …
Abstract
C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than α-human atrial natriuretic peptide (α-hANP). The inhibitory effect of CNP was mimicked by 8-bromo-cGMP. The proliferation of VSMC was also suppressed by CNP more potently than α-hANP, while the peptide was less active for cGMP augmentation and for vasorelaxation than α-hANP in isolated rat aorta. These results suggest that CNP may be a growth regulating factor of VSMC rather than a vasodilator.
Elsevier
