A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker
MM Kleiter, DE Thrall, DE Malarkey, X Ji… - International Journal of …, 2006 - Elsevier
Purpose: Pimonidazole HCl is widely used in immunohistochemical analyses of hypoxia in
normal and malignant tissues. The present study investigates oral administration as a
means of minimizing invasiveness. Methods and Materials: Twelve dogs with confirmed
malignancy received 0.5 g/m2 of pimonidazole HCl: 6 by mouth and 6 by iv infusion. All
dogs received iv CCI-103F as a control. Plasma levels of pimonidazole, pimonidazole N-
oxide, and CCI-103F were measured. Tumor biopsies were formalin fixed, paraffin …
normal and malignant tissues. The present study investigates oral administration as a
means of minimizing invasiveness. Methods and Materials: Twelve dogs with confirmed
malignancy received 0.5 g/m2 of pimonidazole HCl: 6 by mouth and 6 by iv infusion. All
dogs received iv CCI-103F as a control. Plasma levels of pimonidazole, pimonidazole N-
oxide, and CCI-103F were measured. Tumor biopsies were formalin fixed, paraffin …
