We are now aware that extracorporeal photopheresis (ECP)–in which a patient's leukocytes
are isolated, passed through an ultrathin clear plastic plate, and exposed to 8-
methoxypsoralen (8-MOP) and ultraviolet A light prior to reinfusion–is a simple and efficient
dendritic cell (DC) therapy and the first FDA approved selective immunotherapy for cancer.
DCs, as the most effective antigen presenting cells (APCs), are central to many ongoing
efforts to stimulate immune responses to cancer cells. Moreover, ECP has not only …