Complete molecular remission during biologic response modifier therapy for Sezary syndrome is associated with enhanced helper T type 1 cytokine production and …
EK Yoo, M Cassin, SR Lessin, AH Rook - Journal of the American Academy …, 2001 - Elsevier
Background: Cutaneous T-cell lymphoma (CTCL) is a clonally derived, skin-invasive
malignancy of CD4+ T lymphocytes with the phenotype of mature helper T cells. Advancing
stages of CTCL are associated with depressed cell-mediated immunity, increased
production of T helper type 2 cytokines and decreased levels of T helper type 1 cytokines.
Objective: Our purpose was to evaluate the cytokine secretion pattern and cell-mediated
cytotoxicity in peripheral blood mononuclear cells of patients with Sézary syndrome in …
malignancy of CD4+ T lymphocytes with the phenotype of mature helper T cells. Advancing
stages of CTCL are associated with depressed cell-mediated immunity, increased
production of T helper type 2 cytokines and decreased levels of T helper type 1 cytokines.
Objective: Our purpose was to evaluate the cytokine secretion pattern and cell-mediated
cytotoxicity in peripheral blood mononuclear cells of patients with Sézary syndrome in …