The most common cutaneous lymphoma is mycosis fungoides, a non-Hodgkin's, peripheral T-cell lymphoma. Recent advances in the understanding of the molecular and biologic behavior of T cells in this lymphoma — notably, their ability to home to the skin, function in an activated state, and achieve clonal dominance — have had a tremendous influence on current treatment. In this review, the expanding armamentarium of biologic agents, phototherapeutic and irradiation techniques, and combination regimens available to treat mycosis fungoides is discussed.