De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells: DEPENDENCE ON PROTEIN PHOSPHATASE-1 …
CE Chalfant, K Rathman, RL Pinkerman… - Journal of Biological …, 2002 - ASBMB
Previous studies have demonstrated that several splice variants are derived from both the
caspase 9 and Bcl-x genes in which the Bcl-x splice variant, Bcl-x (L) and the caspase 9
splice variant, caspase 9b, inhibit apoptosis in contrast to the pro-apoptotic splice variants,
Bcl-x (s) and caspase 9. In a recent study, we showed that ceramide induces the
dephosphorylation of SR proteins, a family of protein factors that regulate alternative
splicing. In this study, the regulation of the alternative processing of pre-mRNA of both …
caspase 9 and Bcl-x genes in which the Bcl-x splice variant, Bcl-x (L) and the caspase 9
splice variant, caspase 9b, inhibit apoptosis in contrast to the pro-apoptotic splice variants,
Bcl-x (s) and caspase 9. In a recent study, we showed that ceramide induces the
dephosphorylation of SR proteins, a family of protein factors that regulate alternative
splicing. In this study, the regulation of the alternative processing of pre-mRNA of both …