[HTML][HTML] ACAT-2, a second mammalian acyl-CoA: cholesterol acyltransferase: its cloning, expression, and characterization
S Cases, S Novak, YW Zheng, HM Myers… - Journal of Biological …, 1998 - ASBMB
The synthesis of cholesterol esters by acyl-CoA: cholesterol acyltransferase (ACAT, EC 2.3.
1.26) is an important component of cellular cholesterol homeostasis. Cholesterol ester
formation also is hypothesized to be important in several physiologic processes, including
intestinal cholesterol absorption, hepatic lipoprotein production, and macrophage foam cell
formation in atherosclerotic lesions. Mouse tissue expression studies and the disruption of
the mouse ACAT gene (Acact) have indicated that more than one ACAT exists in mammals …
1.26) is an important component of cellular cholesterol homeostasis. Cholesterol ester
formation also is hypothesized to be important in several physiologic processes, including
intestinal cholesterol absorption, hepatic lipoprotein production, and macrophage foam cell
formation in atherosclerotic lesions. Mouse tissue expression studies and the disruption of
the mouse ACAT gene (Acact) have indicated that more than one ACAT exists in mammals …
